The Metabolic Syndrome Institute Literature Watch features
the latest articles on the metabolic syndrome.
Click on the links below to view the abstracts for each article.

Biomarkers

• Prevalence of metabolic syndrome and serum marker levels in patients with four subtypes of cerebral infarction in Japan.
  (Yokokawa H, et al. J Clin Neurosci. 2008 Jul;15(7):769-73. Epub 2008 Apr 14.)
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Cardiovascular Disease / Cardiovascular Risk

• All-cause and cardiovascular mortality using the different definitions of metabolic syndrome.
  (Benetos A, et al. Am J Cardiol. 2008 Jul 15;102(2):188-91. Epub 2008 May 28.)
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• Metabolic syndrome as a cardiovascular disease risk factor: Patients evaluated in primary care.
  (Cabre JJ, et al. BMC Public Health. 2008 Jul 22;8(1):251. [Epub ahead of print])
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• Metabolic syndrome and left ventricular hypertrophy in the prediction of cardiovascular events: The Strong Heart Study.
  (de Simone G, et al. Nutr Metab Cardiovasc Dis. 2008 Jul 30. [Epub ahead of print])
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• Does the metabolic syndrome add to the diagnosis and treatment of cardiovascular disease?
  (de Zeeuw D, et al. Nat Clin Pract Cardiovasc Med. 2008 Jul;5 Suppl 1:S10-4.)
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• Effects of CPAP on cardiovascular risk profile in patients with severe obstructive sleep apnea and metabolic syndrome.
  (Dorkova Z, et al. Chest. 2008 Jul 14. [Epub ahead of print])
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• Elevated prevalence of obesity, metabolic syndrome, and cardiovascular risk factors in bipolar disorder.
  (Fiedorowicz JG, et al. Ann Clin Psychiatry. 2008 Jul-Sep;20(3):131-7.)
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• The metabolic syndrome and cardiovascular disease: part I.
  (Jiamsripong P, et al. Prev Cardiol. 2008 Summer;11(3):155-61.)
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• Assessment of aortic pulse wave velocity and cardiac diastolic function in subjects with and without the metabolic syndrome: HDL cholesterol is independently associated with cardiovascular function.
  (Roes SD, et al. Diabetes Care. 2008 Jul;31(7):1442-4. Epub 2008 Apr 8.)
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• Comparison of waist circumference versus body mass index in diagnosing metabolic syndrome and identifying apparently healthy subjects at increased risk of cardiovascular disease.
  (Ryan MC, et al. Am J Cardiol. 2008 Jul 1;102(1):40-6. Epub 2008 May 9.)
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• The metabolic syndrome increases cardiovascular mortality in Taiwanese elderly.
  (Wen CJ, et al. Eur J Clin Invest. 2008 Jul;38(7):469-75. Epub 2008 May 23.)
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• Intestinal lipid transport and chylomicron production: Possible links to exacerbated atherogenesis in a rodent model of the metabolic syndrome.
  (Vine DF, et al. Atheroscler Suppl. 2008 Jul 14. [Epub ahead of print])
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• Effect of parental coronary artery disease on adverse effects of the metabolic syndrome and aging on carotid artery intima-media thickness (from the Bogalusa Heart Study).
  (Chen W, et al. Am J Cardiol. 2008 Jul 15;102(2):180-3. Epub 2008 May 28.)
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• Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome.
  (Adiels M, et al. Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1225-36. Review.)
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• Global coronary heart disease risk assessment of individuals with the metabolic syndrome in the U.S.
  (Hoang KC, et al. Diabetes Care. 2008 Jul;31(7):1405-9. Epub 2008 Mar 28.)
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• Intra-abdominal fat and metabolic syndrome are associated with larger infrarenal aortic diameters in patients with clinically evident arterial disease.
  (Gorter PM, et al. J Vasc Surg. 2008 Jul;48(1):114-20. Epub 2008 Apr 28.)
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• The fatty acid binding protein-4 (FABP4) is a strong biomarker of metabolic syndrome and lipodystrophy in HIV-infected patients.
  (Coll B, et al. Atherosclerosis. 2008 Jul;199(1):147-53. Epub 2007 Nov 5.)
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• Metabolic syndrome is a predictor for an ECG sign of no-reflow after primary PCI in patients with acute ST-elevation myocardial infarction.
  (Tartan Z, et al. Nutr Metab Cardiovasc Dis. 2008 Jul;18(6):441-7. Epub 2007 Nov 5.)
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• Metabolic syndrome predicts lower functional recovery in female but not in male patients after an acute cardiac event.
  (Caminiti G, et al. Int J Cardiol. 2008 Jul 5. [Epub ahead of print])
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Diabetes

• Risks for type-2 diabetes associated with the metabolic syndrome and the interaction between impaired fasting glucose and other components of metabolic syndrome the study from Jiangsu, China of 5 years follow-up.
  (Liu SJ, et al. Diabetes Res Clin Pract. 2008 Jul;81(1):117-23. Epub 2008 May 15.)
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• Serum resistin is positively correlated with the accumulation of metabolic syndrome factors in type 2 diabetes.
  (Osawa H, et al. Clin Endocrinol (Oxf). 2008 Jul;69(1):74-80. Epub 2008 Jul 1.)
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• Aggravation of albuminuria by metabolic syndrome in type 2 diabetic Asian subjects.
  (Lee IT, et al. Diabetes Res Clin Pract. 2008 Jul 14. [Epub ahead of print])
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Diet, Nutrition & Metabolism

• Patterns of alcohol consumption and the metabolic syndrome.
  (Fan AZ, et al. J Clin Endocrinol Metab. 2008 Jul 15. [Epub ahead of print])
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• Gravinol ameliorates high-fructose-induced metabolic syndrome through regulation of lipid metabolism and proinflammatory state in rats.
  (Yokozawa T, et al. J Agric Food Chem. 2008 Jul 9;56(13):5026-32. Epub 2008 Jun 10.)
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• Fat overload aggravates oxidative stress in patients with the metabolic syndrome.
  (Cardona F, et al. Eur J Clin Invest. 2008 Jul;38(7):510-5. Epub 2008 May 16.)
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• Plasma copper, zinc, and selenium levels and correlates with metabolic syndrome components of lebanese adults.
  (Obeid O, et al. Biol Trace Elem Res. 2008 Summer;123(1-3):58-65. Epub 2008 Feb 21.)
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• Botanicals as epigenetic modulators for mechanisms contributing to development of metabolic syndrome.
  (Kirk H, et al. Metabolism. 2008 Jul;57(7 Suppl 1):S16-23.)
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• Relation of 25-hydroxyvitamin D and parathyroid hormone levels with metabolic syndrome among US adults.
  (Reis JP, et al. Eur J Endocrinol. 2008 Jul;159(1):41-8. Epub 2008 Apr 21.)
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• Strategies for assessment of botanical action on metabolic syndrome in the mouse and evidence for a genotype-specific effect of Russian tarragon in the regulation of insulin sensitivity.
  (Zuberi AR. Metabolism. 2008 Jul;57(7 Suppl 1):S10-5.)
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• Influence of uric acid and gamma-glutamyltransferase on total antioxidant capacity and oxidative stress in patients with metabolic syndrome.
  (Simão AN, et al. Nutrition. 2008 Jul-Aug;24(7-8):675-81. Epub 2008 May 21.)
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Drug Therapy

• The effects of low-dose simvastatin and ezetimibe compared to high-dose simvastatin alone on post-fat load endothelial function in patients with metabolic syndrome: A randomized double-blind crossover trial.
  (Olijhoek JK, et al. J Cardiovasc Pharmacol. 2008 Jul 29. [Epub ahead of print])
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• Simvastatin reduces circulating plasminogen activator inhibitor 1 activity in volunteers with the metabolic syndrome.
  (Wang L, et al. Metab Syndr Relat Disord. 2008 Summer;6(2):149-52.)
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• Effect of irbesartan on erectile function in patients with hypertension and metabolic syndrome.
  (Baumhäkel M, et al. Int J Impot Res. 2008 Jul 3. [Epub ahead of print])
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Epidemiology

• The metabolic syndrome in Japan.
  (Fujita T. Nat Clin Pract Cardiovasc Med. 2008 Jul;5 Suppl 1:S15-8.)
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• The metabolic syndrome identifies a heterogeneous group of metabolic component combinations in the Asia-Pacific region.
  (Lee CM, et al. Diabetes Res Clin Pract. 2008 Jul 8. [Epub ahead of print])
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Exercise

• Effects of exercise and serum uric acid on the metabolic syndrome for Japanese workers.
  (Kawada T, et al. Metab Syndr Relat Disord. 2008 Summer;6(2):137-41.)
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• Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study.
  (Tjønna AE, et al. Circulation. 2008 Jul 22;118(4):346-54. Epub 2008 Jul 7.)
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• Physical activity is negatively associated with the metabolic syndrome in the elderly.
  (Bianchi G, et al. QJM. 2008 Jul 23. [Epub ahead of print])
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• Physical activity, cardiorespiratory fitness, and the metabolic syndrome in youth.
  (Steele RM, et al. J Appl Physiol. 2008 Jul;105(1):342-51. Epub 2008 Mar 27.)
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Genetics

• Androgen receptor gene CAG repeat length in women with metabolic syndrome.
  (Jääskeläinen J, et al. Gynecol Endocrinol. 2008 Jul;24(7):411-6.)
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• Genome-wide linkage scan for the metabolic syndrome: The GENNID Study.
  (Edwards KL, et al. Obesity (Silver Spring). 2008 Jul;16(7):1596-1601. Epub 2008 Apr 17.)
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• Prioritisation of candidate disease genes for metabolic syndrome by computational analysis of its defining phenotypes.
  (Tiffin N, et al. Physiol Genomics. 2008 Jul 8. [Epub ahead of print])
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Hypertension

• Insight into the genetics of hypertension, a core component of the metabolic syndrome.
  (Pravenec M, et al. Curr Opin Clin Nutr Metab Care. 2008 Jul;11(4):393-7.)
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• Secondary hypertension: obesity and the metabolic syndrome.
  (Singer GM, et al. J Clin Hypertens (Greenwich). 2008 Jul;10(7):567-74.)
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• High-normal blood pressure, impaired glucose regulation and metabolic syndrome have variable impact on central artery stiffness.
  (Aizawa K, et al. Diabetes Res Clin Pract. 2008 Jul;81(1):72-8. Epub 2008 Apr 8.)
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• Blood pressure-independent relations of left ventricular geometry to the metabolic syndrome and insulin resistance: a population-based study.
  (Sundström J, et al. Heart. 2008 Jul;94(7):874-8. Epub 2007 Oct 11.)
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• Relationships between metabolic syndrome and left ventricular mass in hypertensive patients: does sex matter?
  (Mulè G, et al. J Hum Hypertens. 2008 Jul 3. [Epub ahead of print])
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• Pulse pressure amplification, adiposity and metabolic syndrome in subjects under chronic antihypertensive therapy: the role of heart rate.
  (Vergnaud AC, et al. Atherosclerosis. 2008 Jul;199(1):222-9. Epub 2007 Nov 7.)
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• Factor relationships of metabolic syndrome and echocardiographic phenotypes in the HyperGEN study.
  (Huang P, et al. J Hypertens. 2008 Jul;26(7):1360-6.)
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Insulin Resistance / Insulin Sensitivity

• Peroxisome proliferator-activated receptor delta-agonist, GW501516, ameliorates insulin resistance, improves dyslipidaemia in monosodium l-glutamate metabolic syndrome mice.
  (Chen W, et al. Basic Clin Pharmacol Toxicol. 2008 Jul 18. [Epub ahead of print])
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• Inflammatory markers in relation to insulin resistance and the metabolic syndrome.
  (Ingelsson E, et al. Eur J Clin Invest. 2008 Jul;38(7):502-9. Epub 2008 May 16.)
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• Effect of Ramadan fasting on some indices of insulin resistance and components of the metabolic syndrome in healthy male adults.
  (Shariatpanahi ZV, et al. Br J Nutr. 2008 Jul;100(1):147-51. Epub 2007 Dec 6.)
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• Insulin resistance and metabolic syndrome in chronic liver diseases: Old entities with new implications.
  (Tsochatzis EA, et al. Scand J Gastroenterol. 2008 Jul 25:1-9. [Epub ahead of print])
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• The metabolic syndrome, IGF-1, and insulin action.
  (Arai Y, et al. Mol Cell Endocrinol. 2008 Jul 11. [Epub ahead of print])
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• Tumor necrosis factor-alpha antagonism improves vasodilation during hyperinsulinemia in metabolic syndrome.
  (Tesauro M, et al. Diabetes Care. 2008 Jul;31(7):1439-41. Epub 2008 Apr 4.)
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Metabolic Syndrome in Men

• The dark side of testosterone deficiency:I. Metabolic syndrome & erectile dysfunction.
  (Traish AM, et al. J Androl. 2008 Jul 17. [Epub ahead of print])
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Metabolic Syndrome in Women

• Effects of androgens on insulin action in women: is androgen excess a component of female metabolic syndrome?
  (Corbould A. Diabetes Metab Res Rev. 2008 Jul 10. [Epub ahead of print])
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• Prevalence of parameter indicators of obesity and its relationship with metabolic syndrome in urban Moroccan women.
  (Mohammed el A, et al. Am J Hum Biol. 2008 Jul-Aug;20(4):484-6.)
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• Prevalence and predictors of metabolic syndrome among HIV-infected and HIV-uninfected women in the Women's Interagency HIV Study.
  (Sobieszczyk ME, et al. J Acquir Immune Defic Syndr. 2008 Jul 1;48(3):272-80.)
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• Metabolic syndrome, vitamin D and bone status in South Asian women living in Auckland, New Zealand: a randomised, placebo-controlled, double-blind vitamin D intervention.
  (von Hurst PR, et al. BMC Public Health. 2008 Jul 31;8(1):267. [Epub ahead of print])
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• Menopause and the metabolic syndrome: the Study of Women's Health Across the Nation.
  (Janssen I, et al. Arch Intern Med. 2008 Jul 28;168(14):1568-75.)
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• Cardiometabolic risk in polycystic ovary syndrome: a comparison of different approaches to defining the metabolic syndrome.
  (Cussons AJ, et al. Hum Reprod. 2008 Jul 16. [Epub ahead of print])
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Miscellaneous

• A possible association between suspected restrictive pattern as assessed by ordinary pulmonary function test and the metabolic syndrome.
  (Nakajima K, et al. Chest. 2008 Jul 14. [Epub ahead of print])
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• Metabolic syndrome and Alzheimer's disease: a link to a vascular hypothesis?
  (Milionis HJ, et al. CNS Spectr. 2008 Jul;13(7):606-13.)
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• Idiopathic neuropathy patients are at high risk for metabolic syndrome.
  (Smith AG, et al. J Neurol Sci. 2008 Jul 5. [Epub ahead of print])
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• Relationship between lower urinary tract symptoms and metabolic syndrome in a community-based elderly population.
  (Park HK, et al. Urology. 2008 Jul 1. [Epub ahead of print])
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• Interleukin-15 and interleukin-15Ralpha SNPs and associations with muscle, bone, and predictors of the metabolic syndrome.
  (Pistilli EE, et al. Cytokine. 2008 Jul;43(1):45-53. Epub 2008 Jun 2.)
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• MRI total sagittal abdominal diameter as a predictor of metabolic syndrome compared to visceral fat at L4-L5 level.
  (Valsamakis G, et al. Curr Med Res Opin. 2008 Jul;24(7):1853-60. Epub 2008 May 27.)
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• Prevalence and heritability of clusters for diagnostic components of metabolic syndrome: the Oman family study.
  (Lopez-Alvarenga JC, et al. Metab Syndr Relat Disord. 2008 Summer;6(2):129-35.)
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• Glycation does not modify bovine serum albumin (BSA)-induced reduction of rat aortic relaxation: the response to glycated and nonglycated BSA is lost in metabolic syndrome.
  (Rubio-Ruiz ME, et al. Glycobiology. 2008 Jul;18(7):517-25. Epub 2008 May 5.)
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Non-Alcoholic Fatty Liver Disease

• Nonalcoholic fatty liver disease: Hepatic manifestation of obesity and the metabolic syndrome.
  (Daram SR, et al. Postgrad Med. 2008 Jul 31;120(2):E01-E07.)
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• Plasma plasminogen activator inhibitor-1 levels and nonalcoholic fatty liver in individuals with features of metabolic syndrome.
  (de Larrañaga G, et al. Clin Appl Thromb Hemost. 2008 Jul;14(3):319-24. Epub 2007 Dec 26.)
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• Liver diseases and metabolic syndrome.
  (Watanabe S, et al. J Gastroenterol. 2008;43(7):509-18. Epub 2008 Jul 23.)
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• Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease.
  (Schwimmer JB, et al. Circulation. 2008 Jul 15;118(3):277-83. Epub 2008 Jun 30.)
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Obesity

• Serum leptin, abdominal obesity and the metabolic syndrome in individuals with chronic spinal cord injury.
  (Maruyama Y, et al. Spinal Cord. 2008 Jul;46(7):494-9. Epub 2008 Jan 22.)
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• Role of stearoyl-CoA desaturases in obesity and the metabolic syndrome.
  (Popeijus HE, et al. Int J Obes (Lond). 2008 Jul;32(7):1076-82. Epub 2008 Apr 22.)
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• Metabolic syndrome affects fatty acid composition of plasma lipids in obese prepubertal children.
  (Gil-Campos M, et al. Lipids. 2008 Aug;43(8):723-32. Epub 2008 Jul 1.)
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Pediatrics

• Relationship between metabolic syndrome definitions for children and adolescents and intima-media thickness.
  (Reinehr T, et al. Atherosclerosis. 2008 Jul;199(1):193-200. Epub 2007 Nov 26.)
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• The prevalence of the metabolic syndrome among an ethnically/racially diverse group of US 8th grade adolescents and associations with fasting insulin and HOMA-IR levels.
  (The STOPP-T2D Prevention Study Group. Diabetes Care. 2008 Jul 15. [Epub ahead of print])
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• Prevalence of metabolic syndrome and associated risk factors in Brazilian schoolchildren.
  (Seki M, et al. Public Health Nutr. 2008 Jul 24:1-6. [Epub ahead of print])
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• Management of metabolic syndrome in young population.
  (Brandão AP, et al. Am J Ther. 2008 Jul-Aug;15(4):356-61.)
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• Changes in risk variables of metabolic syndrome since childhood in prediabetic and type 2 diabetic subjects: the Bogalusa Heart Study.
  (Nguyen QM, et al. Diabetes Care. 2008 Jul 15. [Epub ahead of print])
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• Identifying metabolic syndrome without blood tests in young adults--The Terneuzen Birth Cohort.
  (de Kroon ML, et al. Eur J Public Health. 2008 Jul 4. [Epub ahead of print])
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• Association of arterial stiffness and endothelial dysfunction with metabolic syndrome in obese children.
  (Mimoun E, et al. J Pediatr. 2008 Jul;153(1):65-70. Epub 2008 Mar 6.)
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• Ethnic differences in metabolic syndrome among overweight and obese children and adolescents: the Oslo Adiposity Intervention Study.
  (Pollestad Kolsgaard ML, et al. Acta Paediatr. 2008 Jul 24. [Epub ahead of print])
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Psychiatric Disorders

• Metabolic syndrome in Italian patients with bipolar disorder.
  (Salvi V, et al. Gen Hosp Psychiatry. 2008 Jul-Aug;30(4):318-23.)
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• Metabolic syndrome in bipolar disorder: a cross-sectional assessment of a Health Management Organization database.
  (Sicras A, et al. Bipolar Disord. 2008 Jul;10(5):607-16.)
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• A comparison of schizophrenia outpatients treated with antipsychotics with and without metabolic syndrome: Findings from the CLAMORS study.
  (Arango C, et al. Schizophr Res. 2008 Jul 5. [Epub ahead of print])
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• Metabolic syndrome in female patients with schizophrenia treated with second generation antipsychotics: a 3-month follow-up.
  (Medved V, et al. J Psychopharmacol. 2008 Jul 17. [Epub ahead of print])
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• Rimonabant in rats with a metabolic syndrome: good news after the depression.
  (Di Marzo V, et al. Br J Pharmacol. 2008 Jul;154(5):915-7. Epub 2008 May 5.)
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• Screening for the metabolic syndrome in community psychiatric patients prescribed antipsychotics: a quality improvement programme.
  (Barnes TR, et al. Acta Psychiatr Scand. 2008 Jul;118(1):26-33.)
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Risk Factors

• Risk for metabolic syndrome predisposes to alterations in the thalamic metabolism.
  (Heikkilä O, et al. Metab Brain Dis. 2008 Jul 22. [Epub ahead of print])
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Sleep Disorders

• Relationship between sleep duration and the metabolic syndrome: Korean National Health and Nutrition Survey 2001.
  (Choi KM, et al. Int J Obes (Lond). 2008 Jul;32(7):1091-7. Epub 2008 May 13.)
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Stroke

• Metabolic syndrome and resistance to IV thrombolysis in middle cerebral artery ischemic stroke.
  (Arenillas JF, et al. Neurology. 2008 Jul 15;71(3):190-5.)
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