The Metabolic Syndrome Institute Literature Watch features
the latest articles on the metabolic syndrome.
Click on the links below to view the abstracts for each article.

Adiponectin

• The proinflammatory mediator CD40 ligand is increased in the metabolic syndrome and modulated by adiponectin.
  (Natal C, et al. J Clin Endocrinol Metab. 2008 Jun;93(6):2319-27. Epub 2008 Mar 18.)
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Apo / Lipoproteins

• Apolipoprotein B/apolipoprotein A-I ratio in relation to various definitions of metabolic syndrome among Saudi patients with type 2 diabetes mellitus.
  (Alfadda AA, et al. Saudi Med J. 2008 Jun;29(6):821-5.)
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• Oxidized to non-oxidized lipoprotein ratios are associated with arteriosclerosis and the metabolic syndrome in diabetic patients.
  (Girona J, et al. Nutr Metab Cardiovasc Dis. 2008 Jun;18(5):380-7. Epub 2007 Sep 29.)
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• Risk stratification of apolipoprotein B, apolipoprotein A1, and apolipoprotein B/AI ratio on the prevalence of the metabolic syndrome: the ATTICA study.
  (Pitsavos C, et al. Angiology. 2008 Jun-Jul;59(3):335-41. Epub 2008 Apr 2.)
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• Small dense LDL-cholesterol relative to LDL-cholesterol is a strong independent determinant of hypoadiponectinemia in metabolic syndrome.
  (Satoh N, et al. Circ J. 2008 Jun;72(6):932-9.)
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Cardiovascular Risk / Cardiovascular Disease

• Long-term outcomes in non-diabetic patients with metabolic syndrome undergoing revascularization for multi-vessel coronary artery disease.
  (Yatskar L, et al. Atherosclerosis. 2008 Jun;198(2):389-95. Epub 2007 Dec 3.)
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Diabetes

• The metabolic syndrome and incident diabetes: Current state of the evidence.
  (Ford ES, et al. Diabetes Care. 2008 Jun 30. [Epub ahead of print])
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• Metabolic syndrome and cardiovascular mortality in older type 2 diabetic patients:
  A longitudinal study.
  (Monami M, et al. J Gerontol A Biol Sci Med Sci. 2008 Jun;63(6):646-9.)
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• Diagnosing metabolic syndrome in type 2 diabetes: Does it matter?
  (Song SH, et al. QJM. 2008 Jun;101(6):487-91. Epub 2008 Mar 19.)
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• Type 2 diabetes mellitus and the metabolic syndrome following sleeve gastrectomy in severely obese subjects.
  (Vidal J, et al. Obes Surg. 2008 Jun 3. [Epub ahead of print])
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• Metabolic syndrome and incidence of type 2 diabetes in patients with manifest vascular disease.
  (Wassink AM, et al. Diab Vasc Dis Res. 2008 Jun;5(2):114-22.)
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Diet, Nutrition and Metabolism

• Ethnic differences in dairy and related nutrient consumption among US adults and their association with obesity, central obesity, and the metabolic syndrome.
  (Beydoun MA, et al. Am J Clin Nutr. 2008 Jun;87(6):1914-25.)
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• High-fat, energy-dense, fast-food-style breakfast results in an increase in oxidative stress in metabolic syndrome.
  (Devaraj S, et al. Metabolism. 2008 Jun;57(6):867-70.)
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• Neuroendocrine deregulation of food intake, adipose tissue and the gastrointestinal system in obesity and metabolic syndrome.
  (Garruti G, et al. J Gastrointestin Liver Dis. 2008 Jun;17(2):193-198.)
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• Bladder dysfunction in rats with metabolic syndrome induced by long-term fructose feeding.
  (Lee WC, et al. J Urol. 2008 Jun;179(6):2470-6. Epub 2008 Apr 23.)
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• Moderate wine consumption in the prevention of metabolic syndrome and its related medical complications.
  (Liu L, et al. Endocr Metab Immune Disord Drug Targets. 2008 Jun;8(2):89-98.)
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• Dietary magnesium intake is related to metabolic syndrome in older Americans.
  (McKeown NM, et al. Eur J Nutr. 2008 Jun;47(4):210-6. Epub 2008 Jun 16.)
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• Plasma copper, zinc, and selenium levels and correlates with metabolic syndrome components of lebanese adults.
  (Obeid O, et al. Biol Trace Elem Res. 2008 Jun;123(1-3):58-65. Epub 2008 Feb 21.)
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• Metabolic syndrome and the role of dietary lifestyles in Alzheimer's disease.
  (Pasinetti GM, et al. J Neurochem. 2008 Jun 2. [Epub ahead of print])
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• High multi-vitamin intake by Wistar rats during pregnancy results in increased food intake and components of the metabolic syndrome in the male offspring.
  (Szeto IM, et al. Am J Physiol Regul Integr Comp Physiol. 2008 Jun 4. [Epub ahead of print])
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• Gravinol ameliorates high-fructose-induced metabolic syndrome through regulation of lipid metabolism and proinflammatory state in rats.
  (Yokozawa T, et al. J Agric Food Chem. 2008 Jul 9;56(13):5026-32. Epub 2008 Jun 10.)
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Drug Therapy

• Atorvastatin and fenofibrate have comparable effects on VLDL-apolipoprotein C-III kinetics in men with the metabolic syndrome.
  (Chan DC, et al. Arterioscler Thromb Vasc Biol. 2008 Jun 19. [Epub ahead of print])
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• The effects of orlistat and fenofibrate, alone or in combination, on high-density lipoprotein subfractions and pre-beta1-HDL levels in obese patients with metabolic syndrome.
  (Filippatos TD, et al. Diabetes Obes Metab. 2008 Jun;10(6):476-83. Epub 2007 Apr 24.)
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• Fenofibrate improves endothelial function and decreases thrombin-activatable fibrinolysis inhibitor concentration in metabolic syndrome.
  (Kilicarslan A, et al. Blood Coagul Fibrinolysis. 2008 Jun;19(4):310-4.)
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• Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese zucker rats.
  (Rivera L, et al. Obesity (Silver Spring). 2008 Jun 12. [Epub ahead of print])
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• Fenofibrate reduces fasting and postprandial inflammatory responses among hypertriglyceridemia patients with the metabolic syndrome.
  (Rosenson RS, et al. Atherosclerosis. 2008 Jun;198(2):381-8. Epub 2008 Feb 1.)
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• Negative impact of metabolic syndrome on the responsiveness to sildenafil in Japanese men.
  (Suetomi T, et al. J Sex Med. 2008 Jun;5(6):1443-50. Epub 2008 Jan 18.)
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Epidemiology

• Metabolic syndrome and cognitive decline in chinese older adults: Results from the singapore longitudinal ageing studies.
  (Ho RC, et al. Am J Geriatr Psychiatry. 2008 Jun;16(6):519-22.)
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• Glutathione peroxidase 1 Pro198Leu variant contributes to the metabolic syndrome in men in a large Japanese cohort.
  (Kuzuya M, et al. Am J Clin Nutr. 2008 Jun;87(6):1939-44.)
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• Gender differences in C-reactive protein, interleukin-1 receptor antagonist and adiponectin levels in the metabolic syndrome: a population-based study.
  (Saltevo J, et al. Diabet Med. 2008 Jun;25(6):747-50. Epub 2008 Apr 23.)
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• Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies.
  (Sattar N, et al. Lancet. 2008 Jun 7;371(9628):1927-35. Epub 2008 May 22.)
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• Relationship between ghrelin and the metabolic syndrome in the elderly: A longitudinal population-based study.
  (Serra-Prat M, et al. Clin Endocrinol (Oxf). 2008 Jun 10. [Epub ahead of print])
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• Distinct component profiles and high risk among African Americans with metabolic syndrome: The Jackson Heart Study.
  (Taylor H, et al. Diabetes Care. 2008 Jun;31(6):1248-53. Epub 2008 Mar 10.)
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Exercise

• Short-term training effects on diastolic function in obese persons with the metabolic syndrome.
  (Baynard T, et al. Obesity (Silver Spring). 2008 Jun;16(6):1277-83. Epub 2008 Apr 3.)
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• The effect of metabolic syndrome components on exercise performance in patients with intermittent claudication.
  (Gardner AW, et al. J Vasc Surg. 2008 Jun;47(6):1251-8. Epub 2008 Apr 14.)
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• Cardiorespiratory fitness as a feature of metabolic syndrome in older men and women: the Dose-Responses to Exercise Training study (DR's EXTRA).
  (Hassinen M, et al. Diabetes Care. 2008 Jun;31(6):1242-7. Epub 2008 Mar 10.)
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• The metabolic syndrome and the immediate antihypertensive effects of aerobic exercise: a randomized control design.
  (Pescatello LS, et al. BMC Cardiovasc Disord. 2008 Jun 10;8:12.)
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Genetics

• FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome.
  (Attaoua R, et al. Biochem Biophys Res Commun. 2008 Jun 20. [Epub ahead of print])
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• Prevalence and heritability of the metabolic syndrome and its individual components in a Dutch isolate: The Erasmus Rucphen Family (ERF) study.
  (Henneman P, et al. J Med Genet. 2008 Jun 26. [Epub ahead of print])
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• Genetics of metabolic syndrome: Is there a role for phenomics?
  (Joy T, et al. Curr Atheroscler Rep. 2008 Jun;10(3):201-8.)
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• Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol.
  (Love-Gregory L, et al. Hum Mol Genet. 2008 Jun 1;17(11):1695-704. Epub 2008 Feb 27.)
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• Association of TCF7L2 polymorphism with diabetes mellitus, metabolic syndrome, and markers of beta cell function and insulin resistance in a population-based sample of Emirati subjects.
  (Saadi H, et al. Diabetes Res Clin Pract. 2008 Jun;80(3):392-8. Epub 2008 Feb 20.)
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• Association between oxidative DNA damage and telomere shortening in circulating endothelial progenitor cells obtained from metabolic syndrome patients with coronary artery disease.
  (Satoh M, et al. Atherosclerosis. 2008 Jun;198(2):347-53. Epub 2007 Nov 5.)
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• Overindulgence and metabolic syndrome: Is FoxO1 a missing link?
  (Sparks JD, et al. J Clin Invest. 2008 Jun;118(6):2012-5.)
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• Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome.
  (Yamada Y, et al. Int J Mol Med. 2008 Jun;21(6):801-8.)
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Hypertension

• Hypertension as part of the metabolic syndrome.
  (Cheung BM. J Hum Hypertens. 2008 Jun 12. [Epub ahead of print])
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• Metabolic syndrome and target organ damage: Role of blood pressure.
  (Cuspidi C, et al. Expert Rev Cardiovasc Ther. 2008 Jun;6(5):731-43.)
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• Aldosterone in salt-sensitive hypertension and metabolic syndrome.
  (Fujita T. J Mol Med. 2008 Jun;86(6):729-34. Epub 2008 Apr 25.)
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• Plasma aldosterone and its relationships with left ventricular mass in essential hypertensive patients with the metabolic syndrome.
  (Mulè G, et al. Am J Hypertens. 2008 Jun 26. [Epub ahead of print])
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• Predictive value of prehypertension for metabolic syndrome, diabetes, and coronary heart disease among turks.
  (Onat A, et al. Am J Hypertens. 2008 Jun 12. [Epub ahead of print])
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• The metabolic syndrome: Similar deleterious impact on all-cause mortality in hypertensive and normotensive subjects.
  (Pannier B, et al. J Hypertens. 2008 Jun;26(6):1223-8.)
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• Peripheral wave reflection and endothelial function in untreated essential hypertensive patients with and without the metabolic syndrome.
  (Plantinga Y, et al. J Hypertens. 2008 Jun;26(6):1216-22.)
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Insulin Resistance

• Metabolic syndrome: from insulin resistance to adipose tissue dysfunction.
  (Camera A, et al. Minerva Med. 2008 Jun;99(3):307-321.)
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• Identifying subjects with insulin resistance by using the modified criteria of metabolic syndrome.
  (Hsieh CH, et al. J Korean Med Sci. 2008 Jun;23(3):465-9.)
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• Insulin resistance and the metabolic syndrome.
  (Lann D, et al. Minerva Med. 2008 Jun;99(3):253-62.)
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Liver Disease

• Metabolic syndrome, insulin resistance and adiponectin level in patients with chronic hepatitis C.
  (Grigorescu M, et al. J Gastrointestin Liver Dis. 2008 Jun;17(2):147-154.)
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• Hepatitis C virus infection: Molecular pathways to metabolic syndrome.
  (Sheikh MY, et al. Hepatology. 2008 Jun;47(6):2127-33. Review.)
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Markers

• Impact of inflammatory markers on cardiovascular mortality in patients with metabolic syndrome.
  (Espinola-Klein C, et al. Eur J Cardiovasc Prev Rehabil. 2008 Jun;15(3):278-284.)
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• Impact of the metabolic syndrome on the predictive values of new risk markers in the general population.
  (Olsen MH, et al. J Hum Hypertens. 2008 Jun 5. [Epub ahead of print])
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Metabolic Syndrome in Men

• Lower sex hormone-binding globulin is more strongly associated with metabolic syndrome than lower total testosterone in older men: The Health in Men Study.
  (Chubb SA, et al. Eur J Endocrinol. 2008 Jun;158(6):785-92.)
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• Metabolic syndrome in men with Klinefelter's syndrome.
  (Ishikawa T, et al. Urology. 2008 Jun;71(6):1109-13. Epub 2008 May 2.)
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• Inverse association of testosterone and the metabolic syndrome in men is consistent across race and ethnic groups.
  (Kupelian V, et al. J Clin Endocrinol Metab. 2008 Jun 17. [Epub ahead of print])
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• Independent prediction of metabolic syndrome by plasma fibrinogen in men, and predictors of elevated levels.
  (Onat A, et al. Int J Cardiol. 2008 Jun 24. [Epub ahead of print])
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Metabolic Syndrome in Women

• Does prevalence of the metabolic syndrome in women with coronary artery disease differ by the ATP III and IDF criteria?
  (Brown TM, et al. J Womens Health (Larchmt). 2008 Jun;17(5):841-7.)
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• Cardiovascular risks and metabolic syndrome in Hong Kong Chinese women with polycystic ovary syndrome.
  (Cheung LP, et al. Hum Reprod. 2008 Jun;23(6):1431-8. Epub 2008 Mar 21.)
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• Impact of metabolic syndrome on coronary plaque vulnerability in Japanese women with acute coronary syndrome.
  (Kato M, et al. Circ J. 2008 Jun;72(6):940-5.)
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• Metabolic syndrome components in relation to risk of cataract extraction: A prospective cohort study of women.
  (Lindblad BE, et al. Ophthalmology. 2008 Jun 4. [Epub ahead of print])
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• Does insulin resistance, visceral adiposity, or a sex hormone alteration underlie the metabolic syndrome? Studies in women.
  (Phillips GB, et al. Metabolism. 2008 Jun;57(6):838-44.)
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• The prevalence of metabolic syndrome among US women of childbearing age.
  (Ramos RG, et al. Am J Public Health. 2008 Jun;98(6):1122-7. Epub 2008 Apr 29.)
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Miscellaneous

• Endothelial function and arterial stiffness in normotensive normoglycemic first-degree relatives of diabetic patients are independent of the metabolic syndrome.
  (Scuteri A, et al. Nutr Metab Cardiovasc Dis. 2008 Jun;18(5):349-56. Epub 2007 Nov 1.)
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• Cytokines as a common components of two different disorders: Metabolic syndrome and hemophagocytic lymphohystiositosis.
  (Siklar Z, et al. Exp Clin Endocrinol Diabetes. 2008 Jun 3. [Epub ahead of print])
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• Metabolic syndrome, haemostasis and thrombosis.
  (Alessi MC, et al. Thromb Haemost. 2008 Jun;99(6):995-1000.)
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• Similar increase in oxidative stress after fat overload in persons with baseline hypertriglyceridemia with or without the metabolic syndrome.
  (Cardona F, et al. Clin Biochem. 2008 Jun;41(9):701-5. Epub 2008 Mar 13.)
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• Transient prenatal androgen exposure produces metabolic syndrome in adult female rats.
  (Demissie M, et al. Am J Physiol Endocrinol Metab. 2008 Jun 10. [Epub ahead of print])
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Modeling / Innovative Techniques

• Impaired capsaicin-induced relaxation of coronary arteries in a porcine model of the metabolic syndrome.
  (Bratz IN, et al. Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2489-96. Epub 2008 Apr 4.)
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• Beneficial effect of coenzyme Q10 on increased oxidative and nitrative stress and inflammation and individual metabolic components developing in a rat model of metabolic syndrome.
  (Kunitomo M, et al. J Pharmacol Sci. 2008 Jun 20;107(2):128-137. Epub 2008 Jun 5.)
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• Comparison of vasculoprotective effects of benidipine and losartan in a rat model of metabolic syndrome.
  (Matsuzaki G, et al. Eur J Pharmacol. 2008 Jun 10;587(1-3):237-42. Epub 2008 Apr 9.)
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• Metabolic syndrome: Comparison of the two commonly used animal models.
  (Oron-Herman M, et al. Am J Hypertens. 2008 Jun 19. [Epub ahead of print])
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Obesity

• Obesity; epiphenomenon or cause of metabolic syndrome?
  (Lois K, et al. Int J Clin Pract. 2008 Jun;62(6):932-8.)
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Pediatrics

• Prevalence of metabolic syndrome (MS) in children and adolescents with varying degrees of obesity.
  (Calcaterra V, et al. Clin Endocrinol (Oxf). 2008 Jun;68(6):868-72. Epub 2007 Nov 2.)
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• On the use of a continuous metabolic syndrome score in pediatric research.
  (Eisenmann JC. Cardiovasc Diabetol. 2008 Jun 5;7:17.)
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• The prevalence of the metabolic syndrome among an ethnically/racially diverse group of US 8th grade adolescents and associations with fasting insulin and HOMA-IR levels.
  (Jago R. Diabetes Care. 2008 Jun 30. [Epub ahead of print])
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• Relationship between the change in overweight status from childhood to adolescence and metabolic syndrome phenotypes: a 9-year retrospective study.
  (Kim KR, et al. Eur J Clin Nutr. 2008 Jun;62(6):748-53. Epub 2007 May 16.)
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• Presence of the metabolic syndrome in obese adolescents predicts impaired glucose tolerance and nonalcoholic fatty liver disease.
  (Love-Osborne KA, et al. J Adolesc Health. 2008 Jun;42(6):543-8. Epub 2008 Mar 4.)
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• Relationship between screen time and metabolic syndrome in adolescents.
  (Mark AE, et al. J Public Health (Oxf). 2008 Jun;30(2):153-60. Epub 2008 Mar 28.)
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• Evidence of metabolic syndrome in lean children with premature pubarche at diagnosis.
  (Mathew RP, et al. Metabolism. 2008 Jun;57(6):733-40.)
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• The pediatric metabolic syndrome.
  (Morrison JA, et al. Minerva Med. 2008 Jun;99(3):269-87.)
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• Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease.
  (Schwimmer JB, et al. Circulation. 2008 Jun 30. [Epub ahead of print])
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• Menstrual health and the metabolic syndrome in adolescents.
  (Tfayli H, et al. Ann N Y Acad Sci. 2008 Jun;1135:85-94.)
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Psychological Factors

• Depressive symptoms and metabolic syndrome: Is inflammation the underlying link?
  (Capuron L, et al. Biol Psychiatry. 2008 Jun 30. [Epub ahead of print])
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Risk Factors

• Association between television viewing and the risk of metabolic syndrome in a community-based population.
  (Chang PC, et al. BMC Public Health. 2008 Jun 3;8:193.)
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• Independent associations between metabolic syndrome, diabetes mellitus and atherosclerosis: observations from the Dallas Heart Study.
  (Chen K, et al. Diab Vasc Dis Res. 2008 Jun;5(2):96-101.)
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• Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk.
  (Després JP, et al. Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1039-49. Epub 2008 Mar 20. Review. Erratum in: Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):e151.)
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• Bilateral oophorectomy before 50 years of age is significantly associated with the metabolic syndrome and Framingham risk score: a controlled, population-based study (HUNT-2).
  (Dørum A, et al. Gynecol Oncol. 2008 Jun;109(3):377-83. Epub 2008 Apr 14.)
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• Association between BMI and metabolic syndrome and adenomatous colonic polyps in Korean men.
  (Lee GE, et al. Obesity (Silver Spring). 2008 Jun;16(6):1434-9. Epub 2008 Apr 3.)
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• The association of C-reactive protein to reduced forced vital capacity in a non-smoking U.S. population with metabolic syndrome and diabetes.
  (Lee HM, et al. Diabetes Care. 2008 Jun 30. [Epub ahead of print])
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• Association of brominated flame retardants with diabetes and metabolic syndrome in the United States population: 2003-2004.
  (Lim JS, et al. Diabetes Care. 2008 Jun 16. [Epub ahead of print])
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• Significant associations of metabolic syndrome and its components with silent lacunar infarction in middle aged subjects.
  (Park K, et al. J Neurol Neurosurg Psychiatry. 2008 Jun;79(6):719-21. Epub 2008 Feb 12.)
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• Serum urate, metabolic syndrome, and cardiovascular risk factors. A population-based study.
  (Puig JG, et al. Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):620-623.)
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• Interleukin-15 and interleukin-15Ralpha SNPs and associations with muscle, bone, and predictors of the metabolic syndrome.
  (Pistilli EE, et al. Cytokine. 2008 Jul;43(1):45-53. Epub 2008 Jun 2.)
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• Barrett esophagus: prevalence of central adiposity, metabolic syndrome, and a proinflammatory state.
  (Ryan AM, et al. Ann Surg. 2008 Jun;247(6):909-15.)
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• Eating meals irregularly: A novel environmental risk factor for the metabolic syndrome.
  (Sierra-Johnson J, et al. Obesity (Silver Spring). 2008 Jun;16(6):1302-7. Epub 2008 Apr 3.)
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• Uric acid and the development of metabolic syndrome in women and men.
  (Sui X, et al. Metabolism. 2008 Jun;57(6):845-52.)
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• Psoriasis and the metabolic syndrome.
  (Gottlieb AB, et al. J Drugs Dermatol. 2008 Jun;7(6):563-72.)
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Screening & Diagnosis

• Diagnosis of insulin resistance in hypertensive patients by the metabolic syndrome: AHA vs. IDF definitions.
  (Hwu CM, et al. Int J Clin Pract. 2008 Jun 16. [Epub ahead of print])
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• Clinical and laboratory diagnosis of the metabolic syndrome.
  (Olufadi R, et al. J Clin Pathol. 2008 Jun;61(6):697-706.)
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Treatment & Management

• Optimizing management of metabolic syndrome to reduce risk: Focus on life-style.
  (Bianchi C, et al. Intern Emerg Med. 2008 Jun;3(2):87-98. Epub 2008 Feb 13.)
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• Traditional chinese medicine in treatment of metabolic syndrome.
  (Yin J, et al. Endocr Metab Immune Disord Drug Targets. 2008 Jun;8(2):99-111.)
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Sleep Disorders

• Obstructive sleep apnea and cardiovascular disease: role of the metabolic syndrome and its components.
  (Jean-Louis G, et al. J Clin Sleep Med. 2008 Jun 15;4(3):261-72.)
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Stroke

• Arterial stiffness, metabolic syndrome and inflammation amongst Asian ischaemic stroke patients.
  (De Silva DA, et al. Eur J Neurol. 2008 Jun 12. [Epub ahead of print])
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